Nociceptin
CAS No. : 170713-75-4
(Synonyms: Orphanin FQ)
| Size | Price | Stock |
|---|---|---|
| 1mg | $92 | In-stock |
| 5mg | $290 | In-stock |
| 10mg | $470 | In-stock |
| 25mg | $950 | In-stock |
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| Cat. No. : | HY-P0183 |
| M.Wt: | 1809.04 |
| Formula: | C79H129N27O22 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 50 mg/mL;DMSO : 50 mg/mL (ultrasonic) |
Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic. In Vitro: Nociceptin (1 μg/mL) significantly prevents LPS (10 ng/mL)-stimulated cell migration whereas it is ineffective when added alone. Nociceptin (1 nM-10 μM) elicits a concentration-dependent blockade of LPS-mediated cell migration, with a maximal effect at 1 and 10 μM. Nociceptin counteracts LPS-induced elevation of IL-1β mRNA levels. Nociceptin (1 μM) and NNC 55-0396 induce apoptotic cell death in U87 cells. Nociceptin (1 μM) counteracts LPS-induced [Ca2+]i increase in U87 cells via β-arrestin 2. Nociceptin counteracts the LPS-induced phosphorylation of PKC and ERK in U87 cells. Nociceptin inhibits the LPS-mediated transcriptional activation of NF-kB and AP-1 reporter genes[1].
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