SC-236
CAS No. : 170569-86-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $88 | In-stock |
| 10mg | $132 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $825 | In-stock |
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| Cat. No. : | HY-W010983 |
| M.Wt: | 401.79 |
| Formula: | C16H11ClF3N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SC-236 is an orally active COX-2 specific inhibitor (IC50 = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model[1][2][3][4][5].
In Vitro: SC-236 (15 μM, 30 min) suppresses the side effects of NSAIDs and prevented inflammation in vECs subjected to ALSS[1].
SC-236 significantly induces PPARγ expression in HSCs and acted as a potent PPARγ agonist in a luciferase-reporter trans-activation assay[2].
SC-236 strongly inhibits, in a time- and concentration-dependent manner, macrophage
viability[2].
SC-236, either alone or in combination with 15d-PGJ2, induced a marked pro-apoptotic effect in HSCs in culture[2].
SC-236 mediates antitumor effect by modulation of AP-1-signaling pathway[3].
In Vivo: SC-236 (6 mg/kg, gavage) exhibits anti-fibrotic properties in CCl4- treated animals[2].
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