GNE-4997
CAS No. : 1705602-02-3
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| Cat. No. : | HY-16984 |
| M.Wt: | 515.58 |
| Formula: | C25H27F2N5O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity[1]. IC50 & Target: Ki: 0.09 nM (ITK)[1] In Vitro: GNE-4997 inhibits PLC-γ phosphorylation in Jurkat cells by T-cell receptor stimulation with an IC50 of 4 nM [1].
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