AZ-PFKFB3-67
CAS No. : 1704741-11-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $610 | In-stock |
| 100mg | $980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101972 |
| M.Wt: | 455.51 |
| Formula: | C26H25N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 250 mg/mL |
AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1, respectively. AZ-PFKFB3-67 reduces MCL-1. AZ-PFKFB3-67 has neuroprotective activity[1][2][3]. IC50 & Target:IC50: 11 nM (PFKFB3), 159 nM (PFKFB2), 1130 nM (PFKFB1)[1] In Vitro:AZ-PFKFB3-67 (25 μM;) inhibits PFKFB3 activity in cells, as shown by decreased MCL-1 protein levels in both SU-DHL-4 and OCI-LY-1 cells[2]. AZ-PFKFB3-67 (10 nM; 24 h) co-treated with Roxadustat (HY-13426) significantly reverses the enhanced cell death of Roxadustat-treated neurons exposed to oxygen-glucose deprivation[3].
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- AZ-PFKFB3-67
- Cat. No.:
- HY-101972
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