11(Z),14(Z),17(Z)-Eicosatrienoic acid

11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is an unsaturated fatty acid that affects mitochondrial genome maintenance. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid fully incorporates into cell membrane phospholipids and supports the initial induction of cellular respiration, but fails to sustain the continuous replication and retention of mitochondrial genomes. 11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid is applicable to research related to fatty acid acyl chain structure-dependent mitochondrial genome maintenance and mitochondrial biogenesis^[1][2]. In Vitro:11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid (40 μM; 24 h; S. cerevisiae KD115) fully incorporates into cellular phospholipids, accounting for 36 mol% of the phospholipid fatty acid composition. However, this full incorporation still fails to prevent the formation of petite mutants, indicating that its effect does not simply result from the inability of fatty acids to incorporate into membrane phospholipids^[1].
11 (Z),14 (Z),17 (Z)-Eicosatrienoic acid supports an increase in cellular respiratory activity from approximately 0.3 to approximately 1.0 nmol O₂/min/10⁶ cells during the relief of respiratory inhibition in S. cerevisiae KD115, which is comparable to cis-8,11,14-eicosatrienoic acid that maintains mitochondrial replication, indicating that the formation of a large number of petite mutants does not result from impaired early cellular respiratory induction^[1].