L-NMMA


CAS No. : 17035-90-4

(Synonyms: Tilarginine; Methylarginine)

17035-90-4
Price and Availability of CAS No. : 17035-90-4
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Cat. No. : HY-18732
M.Wt: 188.23
Formula: C7H16N4O2
Purity: >98 %
Solubility: H2O : 100 mg/mL (ultrasonic)
Introduction of 17035-90-4 :

L-NMMA (Tilarginine) is a non-selective and competitive inhibitor of nitric oxide synthase. L-NMMA inhibits three subtypes, namely nNOS, eNOS, and iNOS, and reduces NO production. L-NMMA alleviates mechanical allodynia, thermal hyperalgesia, and choroidal fibrosis. L-NMMA is applicable to research related to nociception, bone cancer pain, and myopia[1][2][3]. In Vivo:L-NMMA (50 µg; i.t.; single administration) significantly alleviates bone cancer-induced mechanical allodynia and thermal hyperalgesia in mice at 2 and 12 h post-treatment[1].
L-NMMA (20 nmol; intravitreal injection; once every other day; 2 to 4 weeks) alleviates choroidal fibrosis and delays myopia progression by inhibiting the NO signaling pathway in lens-induced myopic guinea pigs[2].

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