Secretin (swine)

Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism^[1][2]. In Vitro: Secretin (swine) (10^-7M, 10^-6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling^[2].
Secretin (10^-7M, 10^-6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines^[2][3][4]. In Vivo: Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice^[2].