11-Keto-beta-boswellic acid
CAS No. : 17019-92-0
(Synonyms: 11-Keto-β-boswellic acid)
| Size | Price | Stock |
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| 1mg | $70 | In-stock |
| 5mg | $170 | In-stock |
| 10mg | $270 | In-stock |
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| Cat. No. : | HY-N2056 |
| M.Wt: | 470.68 |
| Formula: | C30H46O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production[1].
IC50 & Target:5-lipoxygenase, leukotriene, NF-κB[1]
In Vitro:11-?Keto-?beta-?boswellic acid inhibits DPP-4 activity with an IC50 of 1.65?μM[2].
11-?Keto-?beta-?boswellic acid (10 min) inhibits 4-aminopyridine-stimulated glutamate release in rat hippocampal nerve terminals (IC50: 31 μM)[3].
In Vivo:11-?Keto-?beta-?boswellic acid (1-10 mg/kg, p.o., for 21 days) shows anti-diabetic activity in
Streptozotocin (HY-13753)-induced diabetic rats[2].
11-?Keto-?beta-?boswellic acid (10 or 50 mg/kg, i.p.) protects rats against Kainic acid (HY-N2309) (15 mg/kg, i.p.)-induced excitotoxicity[3].
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