JTV-506
CAS No. : 170148-29-5
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| Cat. No. : | HY-19244 |
| M.Wt: | 386.40 |
| Formula: | C19H22N4O5 |
| Purity: | >98 % |
| Solubility: |
JTV-506 is a potent ATP-sensitive potassium channel opener. JTV-506 inhibits Histamine (HY-B1204)-induced contraction of tracheal smooth muscle by activation of KATP channels. JTV-506 attenuates pulmonary vascular tone through its direct action on vascular smooth muscle cells. JTV-506 can be used for pulmonary hypertension research[1][2].
In Vitro:JTV-506 (1 nM-100 μM, 15 min) causes a concentration-dependent inhibition of Histamine-induced contraction in guinea-pig isolated tracheal smooth muscle, and is antagonized by Glibenclamide (HY-15206)[1].
JTV-506 (1 nM-100 μM) relaxes norepinephrine-preconstricted, endothelium-intact arteries from Monocrotaline (MCT) (HY-N0750)-treated and control rats[2].
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