ZD 9379 (sodium)
CAS No. : 170142-29-7
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| Cat. No. : | HY-106969A |
| M.Wt: | 406.77 |
| Formula: | C19H14ClN3NaO4 |
| Purity: | >98 % |
| Solubility: |
ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc[1][2].
In Vivo:ZD 9379 (5 mg/kg, i.v., for 4 hours) sodium significantly reduces the infarct volume in the rat model of permanent middle cerebral artery occlusion (MCAO), inhibits SDs, and improves neurological function[1].
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