(S)-ML753286
CAS No. : 1699720-85-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $550 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1750 | In-stock |
| 50mg | $2750 | In-stock |
| 100mg | $3950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100390 |
| M.Wt: | 355.43 |
| Formula: | C20H25N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor with an IC50 of 0.6 μM on BCRP efflux transporter. IC50 & Target: IC50: 0.6 μM (BCRP efflux transporter)[1] In Vivo: (S)-ML753286 (Compound A) shows the potency and a potent pharmacokinetic (PK) profile in rats (lower clearance [1.54 L/h/kg] and higher bioavailability [123%]). XL388 has moderate terminal elimination half-life with t1/2s of 0.9 h and 2.0 h for 2 mg/kg (iv) and 20 mg/kg (po) in rats, respectively[1].
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