GNE-8324
CAS No. : 1698901-76-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $185 | In-stock |
| 5mg | $455 | In-stock |
| 10mg | $670 | In-stock |
| 25mg | $1140 | In-stock |
| 50mg | $1600 | In-stock |
| 100mg | $2235 | In-stock |
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| Cat. No. : | HY-107498 |
| M.Wt: | 343.42 |
| Formula: | C18H18FN3OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons[1]. In Vitro: A reciprocal allosteric interaction between the GNE-8324 and glutamate binding sites at GluN2A NMDARs such that binding of glutamate enhances binding of GNE-8324 and vice versa. GNE-8324 selectively potentiates GluN2A subunit-containing NMDARs. As a consequence, GNE-8324 potentiation is highly dependent on glutamate site occupancy with enhanced GNE-8324 binding to glutamate-bound NMDARs compared to glutamate-free NMDARs[1].
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