ARS-1323
CAS No. : 1698024-73-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $420 | In-stock |
| 50mg | $660 | In-stock |
| 100mg | $920 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-U00416 |
| M.Wt: | 430.84 |
| Formula: | C21H17ClF2N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
ARS-1323 is a KRAS G12C inhibitor. ARS-1323 specifically binds to the cysteine residue on the mutant K-Ras protein, locks it in the GDP-bound conformation, thereby blocking K-Ras activation and downstream signaling pathways. ARS-1323 can be used to investigate the signal transduction mechanisms and growth characteristics of tumor cells driven by K-Ras G12C[1][2].
IC50 & Target:K-Ras G12C[1]
In Vitro:ARS-1323 blocks the specific binding of [18F]PFPMD to purified GDP-bound KRASG12C oncoprotein[3].
ARS-1323 (0-120 min) significantly reduces the uptake of [18F]PFPMD by KRASG12C-mutant H358 NSCLC cells after 60 min of incubation[3].
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