Ro60-0175 (fumarate)
CAS No. : 169675-09-6
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| Cat. No. : | HY-103140 |
| M.Wt: | 342.75 |
| Formula: | C15H16ClFN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Ro60-0175 fumarate is a potent and selective agonist of 5-HT2C receptor[1]. In Vivo:Ro60-0175 (1 mg/kg; s.c.) fumarate preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1].
Ro60-0175 (0.3, 1, and 3 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1].
Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) fumarate reduces responding and that this effect is prevented by SB242084 pretreatment[1].
Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) fumarate significantly reduces responding on the active lever in the reinstatement group[1].
Ro60-0175 (0.5 mg/kg SB242084; 1 mg/kg Ro60-0175; s.c.; i.p.) fumarate reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1].
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