Glucagon (1-29), bovine, human
CAS No. : 16941-32-5
(Synonyms: Glucagon)
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| 5mg | $238 | In-stock |
| 10mg | $370 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $870 | In-stock |
| 100mg | $1180 | In-stock |
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| Cat. No. : | HY-P0082 |
| M.Wt: | 3482.75 |
| Formula: | C153H225N43O49S |
| Purity: | >98 % |
| Solubility: | H2O : 6.67 mg/mL (ultrasonic;adjust pH to 3 with HCl);DMSO : 2 mg/mL (ultrasonic) |
Glucagon (1-29), bovine, human, porcine is a peptide hormone, produced by pancreatic α-cells. Glucagon stimulates gluconeogenesis[1]. Glucagon (1-29), bovine, human, porcine activates HNF4α and increases HNF4α phosphorylation[2][3].
In Vitro: Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia[1].
Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis[1].
Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes[3].
Glucagon (100 nM) increases phosphorylayion of HNF4α[3].
In Vivo: Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice[4].
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