Afegostat
CAS No. : 169105-89-9
(Synonyms: D-Isofagomine; Isofagomine)
| Size | Price | Stock |
|---|---|---|
| 1mg | $190 | In-stock |
| 5mg | $665 | In-stock |
| 10mg | $1100 | In-stock |
| 25mg | $2350 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-14829 |
| M.Wt: | 147.17 |
| Formula: | C6H13NO3 |
| Purity: | >98 % |
| Solubility: | H2O : 5 mg/mL (ultrasonic) |
Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity[1]. IC50 & Target: GCase[1] In Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates[1].
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