Tyrphostin AG1433
CAS No. : 168835-90-3
(Synonyms: SU1433; AG1433)
| Size | Price | Stock |
|---|---|---|
| 5mg | $125 | In-stock |
| 10mg | $200 | In-stock |
| 50mg | $530 | In-stock |
| 100mg | $790 | In-stock |
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| Cat. No. : | HY-119757 |
| M.Wt: | 266.29 |
| Formula: | C16H14N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation[1][2][3][4]. In Vitro: Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity in glioblastoma cells[1]. In Vivo: Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets[2].
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