Fosbretabulin (disodium)
CAS No. : 168555-66-6
(Synonyms: CA 4DP; CA 4P; Combretastatin A4 disodium phosphate)
| Size | Price | Stock |
|---|---|---|
| 1mg | $42 | In-stock |
| 5mg | $90 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $450 | In-stock |
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| Cat. No. : | HY-17449 |
| M.Wt: | 440.29 |
| Formula: | C18H19Na2O8P |
| Purity: | >98 % |
| Solubility: | H2O : 4.5 mg/mL (ultrasonic;warming);DMF : < 1 mg/mL |
Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[1][3]. IC50 & Target: tubulin[1] In Vitro: Fosbretabulin disodium inhibits growth of leukemia P-388, pancreas BXPC-3, neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, an pharynx FADU, with EC50s of 0.0029, 0.23, 0.00025, 0.00061, 0.00035, 0.00072, and 0.00045 μg/mL, respectively[2]. In Vivo: Fosbretabulin disodium (100 mg/kg; i.p.) increases the mean arterial blood pressure (MABP) at 1 and 6 h after administration and decreases the tumor blood flow in rats[3].
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