Epifriedelanol
CAS No. : 16844-71-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $110 | In-stock |
| 10mg | $180 | In-stock |
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| Cat. No. : | HY-N1931 |
| M.Wt: | 428.73 |
| Formula: | C30H52O |
| Purity: | >98 % |
| Solubility: | DMF : < 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C);THF : 10 mg/mL (ultrasonic);Ethanol |
Epifriedelanol is a triterpenoid found in the root bark of Ulmus davidiana. Epifriedelanol induces apoptosis in DU145 cells. Epifriedelanol has antitumor and anti-inflammatory activities. Epifriedelanol inhibits cellular senescence in human primary cells[1][2][3].
In Vitro:Epifriedelanol (40-60 μg/disc) shows significant in vitro antitumor properties in a potato disc bioassay study[1].
Epifriedelanol (10-50 μg/mL, 3 days) suppresses Doxorubicin (HY-15142A) (adriamycin)-induced cellular senescence as well as replicative senescence in HDFs and HUVECs[2].
Epifriedelanol (10-100 μg/mL, 5 h) represses the levels of p53 and p21 proteins increased by Adriamycin treatment in a dose-dependent manner[2].
Epifriedelanol (3-epifriedelinol) (0-50 μM, 24-72 h) inhibits DU145 and PC3 cells with IC50s of 32.32, and 35.22 μM, respectively at 72 h[3].
Epifriedelanol (5-10μM, 48 h) induces apoptosis in DU145 cells[3].
In Vivo:Epifriedelanol (5-10 mg/kg; p.o.; 21 d) can against Bisphenol A (BPA) (HY-18260)-induced gonadotoxicity and has anti-inflammatory effects[3].
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