OSMI-1
CAS No. : 1681056-61-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $99 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $675 | In-stock |
| 500mg | $2025 | In-stock |
| 1g | $3000 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-119738 |
| M.Wt: | 563.64 |
| Formula: | C28H25N3O6S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans[1][2].
IC50 & Target:IC50: 2.7 μM (O-GlcNAc transferase)[1]
In Vitro: OSMI-1 (50 μM; 24 hours; CHO cells) treatment decreases the viability by about 50% after 24 hours[1].
OSMI-1 (10-100 μM; 24 hours; CHO cells) treatment reduces global O-linked N-acetylglucosamine (O-GlcNAcylation) a dose-dependent manner. OSMI-1 inhibits OGT activity in cells[1].
In Vivo: Mammalian and zebrafish toxicity profiles are strikingly similar, and zebrafish can usually serve as an intermediate step between cell-based evaluation and conventional animal testing. The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031 mg/mL (56 μM, 12 h) and 0.025 mg/mL (45 μM, 24 h) in zebrafish model[2].
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