PD98059
CAS No. : 167869-21-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $60 | In-stock |
| 50mg | $132 | In-stock |
| 100mg | $228 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-12028 |
| M.Wt: | 267.28 |
| Formula: | C16H13NO3 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 33.33 mg/mL (ultrasonic) |
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3].
IC50 & Target:IC50: 2-7 μM (MEK1), 50 μM (MEK2)[1]
In Vitro:PD98059 (20 μM; 24 hours) causes G1-phase cell cycle arrest in OCI-AML-3 cells[4].
PD98059 (10 μM; 22 hours) results in concentration-dependent reductions in the dually phosphorylated forms of ERK1 and ERK2[1].
PD98059 both prevents ERK activation and blocks formation of TDP-43 and HuR-positive SGs[7].
In Vivo:PD98059 (10 mg/kg; i.p.; 1 and 6 hours after Zymosan) significantly reduces the level of p-ERK1/2 in zymosan-injected mice[3].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- PD98059
- Cat. No.:
- HY-12028
- Quantity:
Your information is safe with us.