BMS-8
CAS No. : 1675201-90-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $460 | In-stock |
| 100mg | $680 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-116274 |
| M.Wt: | 494.42 |
| Formula: | C27H28BrNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
BMS-8 inhibits the PD-1/PD-L1 interaction with IC50 of 7.2 μM. BMS-8, binds directly to PD-L1 and induces formation of PD-L1 homodimers, which in turn prevents the interaction with PD-1[1]. In Vitro: BMS-8 tends to have a more stable binding mode with one PD-L1 monomer than the other and the small-molecule inducing PD-L1 dimerization was further stabilized by the non-polar interaction of Ile54, Tyr56, Met115, Ala121, and Tyr123 on both monomers and the water bridges involved in ALys124[2].
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