BMS-1
CAS No. : 1675201-83-8
(Synonyms: PD-1/PD-L1 inhibitor 1)
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $141 | In-stock |
| 25mg | $266 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19991 |
| M.Wt: | 475.58 |
| Formula: | C29H33NO5 |
| Purity: | >98 % |
| Solubility: | DMF : 5 mg/mL (ultrasonic);Methanol : 25 mg/mL (ultrasonic);DMSO : 7.14 mg/mL (ultrasonic) |
BMS-1 is an inhibitor of the PD-1/PD-L1 protein/protein interaction (IC50 between 6 and 100 nM)[1][2].
IC50 & Target:PD1-PDL1[1]
In Vitro: Since PD-1 mediated the exhaustion of natural killer (NK) cell by binding to its ligand PD-L1, BMS-1 (PD-1/PD-L1 inhibitor 1) (1 μM, 3 days) is used to disturb the interaction between PD-1 and PD-L1. Dexamethasone induced increase of PD-1 expression and decrease of cytotoxicity of the co-cultured NK92 cells are reversed by BMS-1[1]. BMS-1, a small-molecule immune checkpoint inhibitor of PD-1/PD-L1, can be used as a therapeutic strategy for tumor immunotherapy[2].
In Vivo: BMS-1 (500 μg/mL; 100 μL; i.p.) significantly increases the survival rates of the mVEGF165b group and mVEGF165b + MUC1 group[3].
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