Zosuquidar (trihydrochloride)
CAS No. : 167465-36-3
(Synonyms: RS 33295-198 trihydrochloride; LY-335979 trihydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $130 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $480 | In-stock |
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| Cat. No. : | HY-50671 |
| M.Wt: | 636.99 |
| Formula: | C32H34Cl3F2N3O2 |
| Purity: | >98 % |
| Solubility: | H2O : 5 mg/mL (ultrasonic);DMSO : 1 mg/mL (ultrasonic) |
Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar trihydrochloride shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research[1][2][3].
IC50 & Target:Ki: 59nM (P-glycoprotein)[1].
In Vitro:Zosuquidar (0.3 μM; 48 h) enhances the cytotoxicity of DNR (substrates for P-glycoproteins) in P-glycoproteins active cell lines[2].
Zosuquidar (5-16 μM; 72 h) treatment alone shows high cytotoxic concentration to drug-sensitive and MDR cell lines[1].
In Vivo:Zosuquidar (intraperitoneal injection; 30, 10, 3, or 1 mg/kg; once daily; 5 d) treatment shows a significant increase in life span[1].
Zosuquidar (intraperitoneal injection; 30 mg/kg; once daily; 5 d) treatment shows the potentiation with a combined of Doxorubicin[1].
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