Rodatristat ethyl
CAS No. : 1673571-51-1
(Synonyms: KAR5585)
| Size | Price | Stock |
|---|---|---|
| 1mg | $368 | In-stock |
| 5mg | $920 | In-stock |
| 10mg | $1450 | In-stock |
| 25mg | $2600 | In-stock |
| 50mg | $3900 | In-stock |
| 100mg | $5850 | In-stock |
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| Cat. No. : | HY-101124 |
| M.Wt: | 590.04 |
| Formula: | C29H31ClF3N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH)[1][2]. IC50 & Target: 5-HT[1]; TPH1[2] In Vivo: Rodatristat ethyl (100 or 200 mg/kg; oral administration; once daily; for 28 days; male Sprague-Dawley rats) treatment decreases erum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduces pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats with monocrotaline (MCT)[1].
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- Cat. No.:
- HY-101124
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