SW208108
CAS No. : 1673557-43-1
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| Cat. No. : | HY-114606 |
| M.Wt: | 456.50 |
| Formula: | C27H24N2O5 |
| Purity: | >98 % |
| Solubility: |
SW208108 is a prodrug of dMe-SW208108, a CYP4F11-activated SCD inhibitor, with an IC50 value of 9 nM. SW208108 undergoes demethylation by CYP4F11 to form the active metabolite dMe-SW208108, thereby inhibiting enzyme function. SW208108 depletes unsaturated fatty acids, induces cytotoxicity in non-small cell lung cancer (NSCLC) cells expressing CYP4F11, and does not affect SCD activity in mouse sebocytes. SW208108 can be used in studies related to NSCLC[1].
In Vitro:SW208108 selectively reduces the viability of four NSCLC cell lines (H2122, H460, HCC44, HCC4017) with an IC50 of 0.014-0.031 μM; it exhibits moderate toxicity against H2073 cells, but shows no toxicity against another seven NSCLC cell lines[1].
SW208108 is selectively metabolized to dMe-SW208108 in H2122 non-small cell lung cancer cells, whereas it remains unmetabolized in H1155 non-small cell lung cancer cells[1].
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