Zosuquidar
CAS No. : 167354-41-8
(Synonyms: RS 33295-198; LY-335979)
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $730 | In-stock |
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| Cat. No. : | HY-15255 |
| M.Wt: | 527.60 |
| Formula: | C32H31F2N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 4.55 mg/mL (ultrasonic;warming;adjust pH to 2 with 1M HCl;heat to 80°C) |
Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research[1][2][3].
In Vitro:Zosuquidar (0.3 μM; 48 h) treatment enhances the cytotoxicity of DNR (substrates for P-glycoproteins) in P-glycoproteins active cell lines[2].
Zosuquidar (5-16 μM; 72 h) treatment alone shows high cytotoxic concentration to drug-sensitive and MDR cell lines[1].
In Vivo:Zosuquidar (intraperitoneal injection; 30, 10, 3, or 1 mg/kg; once daily; 5 d) treatment shows a significant increase in life span[1].
Zosuquidar (intraperitoneal injection; 30 mg/kg; once daily; 5 d) treatment shows the potentiation with a combined of Doxorubicin[1].
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