MS402


CAS No. : 1672684-68-2

1672684-68-2
Price and Availability of CAS No. : 1672684-68-2
Size Price Stock
5mg $45 In-stock
10mg $70 In-stock
25mg $140 In-stock
50mg $225 In-stock
100mg $360 In-stock
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Cat. No. : HY-120000
M.Wt: 370.83
Formula: C20H19ClN2O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 1672684-68-2 :

MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice[1]. In Vivo: Reconstitution with na?ve CD4+CD45RBhi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss[1].

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