PT-2385
CAS No. : 1672665-49-4
| Size | Price | Stock |
|---|---|---|
| 2mg | $110 | In-stock |
| 5mg | $190 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $510 | In-stock |
| 50mg | $715 | In-stock |
| 100mg | $995 | In-stock |
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| Cat. No. : | HY-12867 |
| M.Wt: | 383.34 |
| Formula: | C17H12F3NO4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM[1][2].
IC50 & Target: Kd: <50 nM (HIF-2α)[1]
In Vitro: PT-2385 (PT2385) is a selective antagonist of HIF-2 over HIF-1. PT-2385 is inactive for HIF-1α[1].
In Vivo: PT-2385 (30 or 100 mg/kg; oral gavage; twice daily) result in a rapid, dose-dependent tumor regression[3].
PT-2385 (PT2385) inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT-2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT-2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT-2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31)[1].
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