SD-169
CAS No. : 1670-87-7
| Size | Price | Stock |
|---|---|---|
| 100mg | $40 | In-stock |
| 250mg | $48 | In-stock |
| 1g | $100 | In-stock |
| 5g | $430 | In-stock |
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| 50 g | Get quote | |
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| Cat. No. : | HY-W015445 |
| M.Wt: | 160.18 |
| Formula: | C9H8N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].
IC50 & Target: IC50: 3.2 nM (p38α MAPK), 122 nM (p38β MAPK)[1]
In Vitro: SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1].
SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1].
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