BMS453
CAS No. : 166977-43-1
(Synonyms: BMS-189453)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1300 | In-stock |
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| Cat. No. : | HY-100608 |
| M.Wt: | 380.48 |
| Formula: | C27H24O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[1][2].
In Vitro: BMS453 (1 μM; 11 hours; 184 and HMEC cells) treatment inhibits the proliferation of normal breast cell growth without significantly inducing apoptosis[2].
BMS453 (1 μM; 5 days; 184 and HMEC cells) treatment inhibits normal breast cell proliferation by causing G1 arrest[2].
BMS453 (1 μM; 24-72 hours; 184 cells) treatment induces Rb hypophosphorylation and decrease CDK2 kinase activity. BMS453 increases total p21 protein levels and CDK2-bound p21 protein, but does not change CDK4-bound p21[2].
BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ[2].
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