A-1210477
CAS No. : 1668553-26-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $33 | In-stock |
| 5mg | $70 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $550 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12468 |
| M.Wt: | 850.04 |
| Formula: | C46H55N7O7S |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM[1]. A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner[2]. IC50 & Target: Ki: 0.45 nM (MCL-1), 132 nM (BCL-2), >660 nM (BCL-XL)[1] In Vitro: A-1210477 (10?μM) reduces the amount of BIM co-immunoprecipitated with MCL-1 antibody, and triggers MCL-1 elevation in a variety of cancer cell lines, including the breast cancer cell line HCC-1806. A-1210477 inhibits MCL-1-NOXA interactions with an IC50 of approximately 1?μM, while having no effect on BCL-2-BIM or BCL-XL-BCL-XS interactions. The NSCLC cell lines H2110 and H23 are sensitive to A-1210477 with cell viability IC50<10?μM, confirming that A-1210477 can kill MCL-1-dependent cell lines[1].
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