Doxepin
CAS No. : 1668-19-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $115 | In-stock |
| 50mg | $185 | In-stock |
| 100mg | $300 | In-stock |
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| Cat. No. : | HY-B0725A |
| M.Wt: | 279.38 |
| Formula: | C19H21NO |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis，chronic urticarial，can improve cognitive processes， protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress[1][2][3]. In Vitro: The protective effect of doxepin is associated with the enhancement of PSD-95 and synapsin 1 expression via PI3K/AKT/mTOR signaling pathway[4]. In Vivo: Doxepin (intraperitoneal injection of 1 mg/kg and 5 mg/kg doxepin once a day for 21 days) can protect against the Aβ1-42-induced memory impairment in rats[4].
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