(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride


CAS No. : 16652-71-4

16652-71-4
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Cat. No. : HY-W012071
M.Wt: 241.72
Formula: C12H16ClNO2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 16652-71-4 :

(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is an intermediate in the synthesis of L-proline derivative peptides. (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is a key raw material for the synthesis of apoptosis inhibitor protein (IAP) antagonists and SMAC mimic tripeptide fragments (Boc-MeAla-Tle-Pro-OH). (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride can be used to synthesize divalent quinazoline IAP antagonists[1]. In Vitro:(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride (compound 14) can undergo an amide coupling reaction with Boc-Tle-OH in the HATU/DIPEA/DCM system to generate Boc-Tle-Pro-OBn. After de-Boc by 4M HCl/dioxane, it is coupled with Boc-MeAla-OH and finally debenzylated by H2/Pd-C to obtain tripeptide fragment 16, which is used for the synthesis of divalent quinazoline IAP antagonists[1].

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