| Size | Price | Stock |
|---|---|---|
| 25g | $8 | In-stock |
| 100g | $31 | In-stock |
| 500g | $154 | In-stock |
| 1000g | $307 | In-stock |
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| Cat. No. : | HY-W012071 |
| M.Wt: | 241.72 |
| Formula: | C12H16ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is an intermediate in the synthesis of L-proline derivative peptides. (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride is a key raw material for the synthesis of apoptosis inhibitor protein (IAP) antagonists and SMAC mimic tripeptide fragments (Boc-MeAla-Tle-Pro-OH). (S)-Benzyl pyrrolidine-2-carboxylate hydrochloride can be used to synthesize divalent quinazoline IAP antagonists[1]. In Vitro:(S)-Benzyl pyrrolidine-2-carboxylate hydrochloride (compound 14) can undergo an amide coupling reaction with Boc-Tle-OH in the HATU/DIPEA/DCM system to generate Boc-Tle-Pro-OBn. After de-Boc by 4M HCl/dioxane, it is coupled with Boc-MeAla-OH and finally debenzylated by H2/Pd-C to obtain tripeptide fragment 16, which is used for the synthesis of divalent quinazoline IAP antagonists[1].
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