TAK-615
CAS No. : 1664335-55-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $440 | In-stock |
| 25mg | $790 | In-stock |
| 50mg | $1180 | In-stock |
| 100mg | $1780 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117959 |
| M.Wt: | 419.44 |
| Formula: | C25H22FNO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].
In Vitro: TAK-615 specifically binds to membranes expressing the human LPA1 receptor with estimated Kd high affinity (KdHi) of 1.7±0.5?nM and Kd low affinity (KdLo) of 14.5±12.1?nM[1].
TAK-615 is only able to partially inhibit the LPA response (~?40% at 10?μM with an IC50 of 23±13?nM in β-arrestin assay; 60% at 10?μM, IC50 of 91±30?nM in calcium mobilisation assay) [1].
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