HDGFRP2/PSIP1-IN-1
CAS No. : 166196-54-9
(Synonyms: 4-(4-Bromo-1H-pyrazol-5-yl)pyridine)
| Size | Price | Stock |
|---|---|---|
| 250mg | $10 | In-stock |
| 1g | $17 | In-stock |
| 5g | $69 | In-stock |
| 10g | $111 | In-stock |
| 25g | $229 | In-stock |
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| Cat. No. : | HY-W023758 |
| M.Wt: | 224.06 |
| Formula: | C8H6BrN3 |
| Purity: | >98 % |
| Solubility: |
HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily[1]. IC50 & Target:HDGFRP2/PSIP1-IN-1 与 HDGFRP2 结合的 Kd 值为 7 μM; 与 PSIP1 PWWP 结构域结合的 Kd 值为 27 μM; 对 HDGFRP3 的 Kd 值为 14 μM。
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