GpTx-1
CAS No. : 1661050-12-9
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| Cat. No. : | HY-P1681 |
| M.Wt: | 4073.82 |
| Formula: | C176H271N53O45S7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GpTx-1 is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively[1].
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