BMS-191095
CAS No. : 166095-21-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $260 | In-stock |
| 10mg | $390 | In-stock |
| 25mg | $700 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1280 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14256 |
| M.Wt: | 408.88 |
| Formula: | C22H21ClN4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. BMS-191095 inhibits human platelet aggregation by opening mitochondrial K(ATP) channels[1][2][3]. In Vitro:BMS-191095 (50 μmol/L) induces mitochondrial depolarization of vascular smooth muscle (VSM) cells from SD rats[1]. BMS-191095 (10-100 μmol/L) dose-dependently induces vasodilation in endothelium denuded cerebral arteries[1]. BMS-191095 (50 μmol/L) increases the frequency of calcium sparks in VSM cells[1]. BMS-191095 (0-1500 μM) inhibits human platelet aggregation induced by collagen and thrombin with IC50 values of 63.9 and 104.8 μM, respectively[2]. In Vivo:BMS-191095 (2.5 or 25 μg; intraventricular infusion, 30 min/60 min/24 hours before the induction of ischemia, once) reduces neuronal damage in rats with transient focal cerebral ischemia[3].
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