O4I2
CAS No. : 165682-93-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $80 | In-stock |
| 50mg | $250 | In-stock |
| 100mg | $450 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18772 |
| M.Wt: | 282.75 |
| Formula: | C12H11ClN2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 42 mg/mL |
O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1[1].
In Vitro: O4I2 not only promotes Oct3/4 expression by activating its promoter site, but also stabilize the Oct3/4 protein in HEK293 cells[1].
O4I2 markedly stimulates Oct3/4 even at 5 µM after 72 hrs treatment on the translational
level[1].
O4I2 (20 µM) accumulates Oct3/4 in NCCIT occurred already 2 hrs after incubation, while the detectable Sox2 increase appears much later, implicating compound-mediated activation of Oct3/4 might be different between embryonic kidney HEK293 cells and embryonal carcinoma NCCIT cells[1].
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