Terutroban
CAS No. : 165538-40-9
(Synonyms: S-18886)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $86 | In-stock |
| 25mg | $205 | In-stock |
| 50mg | $370 | In-stock |
| 100mg | $625 | In-stock |
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| Cat. No. : | HY-16991 |
| M.Wt: | 407.91 |
| Formula: | C20H22ClNO4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Terutroban (S-18886) is a selective and orally active thromboxane-prostaglandin (TP) receptor antagonist with an IC50 of 16.4 nM. Terutroban inhibits TXA2 and prostaglandin endoperoxide receptors. Terutroban is a potent antithrombotic agent and possesses anti-atherosclerotic and anti-vasoconstrictor properties[1][2][3]. In Vivo:Terutroban (30 mg/kg; i.g.; once a day; 6 weeks) prevents aortic thickening, inhibits vascular cell proliferation, reduces vascular fibrosis, inhibits the expression of HSP47 and TGF-1β without affecting blood pressure in spontaneously hypertensive stroke-prone rats (SHRSPs)[2].
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