GLPG1837
CAS No. : 1654725-02-6
(Synonyms: ABBV-974)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-111099 |
| M.Wt: | 348.42 |
| Formula: | C16H20N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 250 mg/mL |
GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. IC50 & Target: EC50: 3 nM (F508del CFTR), 339 nM (G551D CFTR)[1] In Vitro: GLPG1837 is a potent CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively. GLPG1837 increases the conductivity of the G551D CFTR channel with obtained potency of 181 nM[1]. GLPG1837 is reversible CFTR potentiator, with a the apparent affinity within a range of 0.2∼2 µM[2].
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