UNC-2170
CAS No. : 1648707-58-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $800 | In-stock |
| 100mg | $1280 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-115531 |
| M.Wt: | 313.23 |
| Formula: | C14H21BrN2O |
| Purity: | >98 % |
| Solubility: | Methanol : 125 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1]. In Vitro: UNC-2170 (500 µM) results in a significant increase in soluble 53BP1 as compared to untreated lysates or lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 µM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1].
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