Efinaconazole
CAS No. : 164650-44-6
(Synonyms: KP-103)
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $77 | In-stock |
| 25mg | $138 | In-stock |
| 50mg | $209 | In-stock |
| 100mg | $319 | In-stock |
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| Cat. No. : | HY-15660 |
| M.Wt: | 348.39 |
| Formula: | C18H22F2N4O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively[1]. Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species[1]. IC50 & Target: Fungal[1] In Vivo: Topical Efinaconazole solution (0.25 to 1%) is dose-dependently effective in treating both dermatophytoses, for 10 guinea pigs with interdigital tinea pedis or tinea corporis is investigated. The follow up study performs on day-30 and day-9 posttreatment demonstrated that the relapse rates for 1% Efinaconazole-treated animals with tinea pedis and for those with tinea corporis are 20 and 30%, respectively. When a single dose of 1% Efinaconazole is applied to the back skin 48 hours before fungal inoculation, 9 of the 10 animals are protected from the dermatophytosis, suggesting that active Efinaconazole is retained in skin tissue for at least 48 hours after dosing[2].
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