HTL14242
CAS No. : 1644645-32-8
(Synonyms: HTL0014242)
| Size | Price | Stock |
|---|---|---|
| 5mg | $210 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $710 | In-stock |
| 50mg | $1150 | In-stock |
| 100mg | $1840 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-W062697 |
| M.Wt: | 310.71 |
| Formula: | C16H8ClFN4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
HTL14242 (HTL0014242) is an advanced and orally active mGlu5 NAM with a pKi?and a pIC50 of 9.3 and 9.2, respectively[1]. HTL14242 can be used for the research of parkinson’s disease[2]. IC50 & Target: pKi: 9.3 (mGlu5); pIC50: 9.2[1] In Vitro: HTL14242 is stable in rat plasma, inactive at the hERG ion-channel, and has a clean profile in vitro assays of cytotoxicity in HepG2 cells, the TC50?is >90 μM[1]. In Vivo: HTL14242 (oral administration; 1, 3, or 10 mg/kg; sacrificed 1 h postdose) emonstrates an excellent, dose-dependent occupancy of mGlu5?receptors from an oral dose, with an estimated ED50?of 0.3 mg/kg[1]. HTL14242 (oral administration; 1 mg/ml) exhibits an oral PK Profile, the t1/2, AUCinf?and F% are 6.5 hours, 3946 ng/h/mL and 80%, respectively in dog[1].
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