Vorasidenib
CAS No. : 1644545-52-7
(Synonyms: AG-881)
| Size | Price | Stock |
|---|---|---|
| 2mg | $90 | In-stock |
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $460 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1100 | In-stock |
| 500mg | $2750 | In-stock |
| 1g | $3850 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-104042 |
| M.Wt: | 414.74 |
| Formula: | C14H13ClF6N6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K. Vorasidenib can be used for the study of grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1/2 mutation[1][2]. IC50 & Target:IC50: 0.04~22 nM (IDH1 R132C, IDH1 R132G, IDH1 R132H, IDH1 R132S), 7~14 nM (IDH2 R140Q), 130 nM (IDH2 R172K)[2] In Vitro:Vorasidenib has strong antiproliferative activity against human glioblastoma U-87 MG pLVX-IDH2 R140Q-neo, fibrosarcoma HT-1080 and neurosphere TS603 cells, all with IC50s of less than 50 nM[2].
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