ML-792
CAS No. : 1644342-14-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1250 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108702 |
| M.Wt: | 551.41 |
| Formula: | C21H23BrN6O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 μM and >100 μM, respectively)[1].
IC50 & Target:IC50: 3 nM (SAE/SUMO1), 11 nM (SAE/SUMO2)[1]
In Vitro:ML-792 (0.0007-5 μM; 4 hours) inhibits SAE and SUMO-pathway activities in HCT116 cells[1].
ML-792 (0.001-10 μM; 72 hours ) inhibits cell proliferation and decreases cancer cell viability in MDA-MB-468, MDA-MB-231, HCT116, Colo-205, and A375[1].
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