PDK1-IN-RS2
CAS No. : 1643958-89-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-114645 |
| M.Wt: | 380.89 |
| Formula: | C15H9ClN2O2S3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1]. IC50 & Target: Kd: 9 μM (PDK1)[1] In Vitro: PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold. The sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge, because the sulfonamide is likely ionized under the crystallization conditions[1].
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