ITI-214
CAS No. : 1642303-38-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $209 | In-stock |
| 10mg | $385 | In-stock |
| 25mg | $693 | In-stock |
| 50mg | $1045 | In-stock |
| 100mg | $1450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12501A |
| M.Wt: | 605.56 |
| Formula: | C29H29FN7O5P |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 30 mg/mL |
ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions[1][2]. In Vitro: ITI-214 expresses >1000-fold greater activity toward PDE1 isoforms compared with the next nearest PDE family enzyme, PDE4D (Ki= 33 nM) and 10,000-300,000-fold selectivity toward all other PDE enzyme families[2]. In Vivo: ITI-214 significantly enhances memory performance in the test with a minimum effective dose of 3 mg/kg[1].
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