Size | Price | Stock |
---|---|---|
1mg | $75 | In-stock |
5mg | $288 | In-stock |
10mg | $340 | In-stock |
50mg | $800 | In-stock |
100mg | $1160 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
We match the lowest price on market. |
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Cat. No. : | HY-100423 |
M.Wt: | 428.29 |
Formula: | C17H10F6N6O |
Purity: | >98 % |
Solubility: | DMSO : ≥ 100 mg/mL (233.49 mM); H2O : < 0.1 mg/mL (insoluble) |
Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces caspase-dependent apoptosis in a panel of leukemic cell lines[1].
IC50 & Target:XPO1[1]
In Vitro: KPT-8602 (2-6 nM; 72 hours) reduces cell viability in leukemia cell lines with EC50s ranging from 25 to 145 nM[1].
KPT-8602 (1 nM; 16 hours) induces apoptosis in leukemia cell lines[1].
In Vivo: KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) shows potent anti-lymphoblastic leukemia activity[1].
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