Eltanexor


CAS No. : 1642300-52-4

(Synonyms: KPT-8602)

1642300-52-4
Price and Availability of CAS No. : 1642300-52-4
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1mg $75 In-stock
5mg $288 In-stock
10mg $340 In-stock
50mg $800 In-stock
100mg $1160 In-stock
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Cat. No. : HY-100423
M.Wt: 428.29
Formula: C17H10F6N6O
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL (233.49 mM); H2O : < 0.1 mg/mL (insoluble)
Introduction of 1642300-52-4 :

Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces caspase-dependent apoptosis in a panel of leukemic cell lines[1]. IC50 & Target:XPO1[1] In Vitro: KPT-8602 (2-6 nM; 72 hours) reduces cell viability in leukemia cell lines with EC50s ranging from 25 to 145 nM[1].
KPT-8602 (1 nM; 16 hours) induces apoptosis in leukemia cell lines[1]. In Vivo: KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) shows potent anti-lymphoblastic leukemia activity[1].

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