ATR-IN-1
CAS No. : 1639974-69-8
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| Cat. No. : | HY-12924 |
| M.Wt: | 349.40 |
| Formula: | C18H19N7O |
| Purity: | >98 % |
| Solubility: |
ATR-IN-1 is a selective ATR inhibitor with an IC50 of 0.5 nM. ATR-IN-1 inhibits the growth of ATM-deficient melanoma. ATR-IN-1 shows no hERG inhibitory effect. ATR-IN-1 can be used for research on melanoma[1].
In Vitro:ATR-IN-1 (Compound 13) inhibits ATR with an IC50 of 0.0005 µM and shows selectivity over ATM (IC50 15 µM) and DNAPK (IC50 >25 µM)[1].
ATR-IN-1 (1 h) does not inhibit mTOR signaling in TSC1−/− MEF cells (IC50 >13 µM)[1].
ATR-IN-1 has a hERG IC50 >30 µM by automated whole-cell electrophysiology[1].
ATR-IN-1 does not inhibit CYP3A4, 2D6, 2C9, or 1A2 (IC50 >24 µM)[1].
ATR-IN-1 (72 h) inhibits the growth of ATM-null HT144 melanoma cells with a GI50 of 0.35 µM after 72 h continuous exposure[1].
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